Karim, a passionate teenager with a promising future as a musician, learns he has schizophrenia. Devastated by this news, and surrounded by his mother and sister, he tries to rediscover his identity, even putting himself in danger.
When fifteen-year-old Tyson attends public school for the first time, his life is changed forever. While helping his father clean up after the football team, Tyson befriends champion marathon runner Aklilu. Never letting his autism hold him back, Tyson becomes determined to run his first marathon in hopes of winning his father's approval. With the help of an unlikely friend and his parents, Tyson learns that with faith in yourself and the courage to take the first step, anything is possible.
Zach Riley is a psychiatrist, who leaves a job at a prestigious university, to take up a job at the privately run mental institution, Millwood. What he doesn't reveal at the time of his appointment is that this was the very place where his novelist father, T.L. Pierson, spent many years of his life.
Matthew, a young schizophrenic, finds himself out on the street when a slumlord tears down his apartment building. Soon, he finds himself in even more dire straits, when he is threatened by Little Leroy, a thug who is one of the tough denizens of the Fort Washington Shelter for Men. He reaches out to Jerry, a streetwise combat veteran, who takes Matthew under his wing as a son. The relationship between these two men grows as they attempt to conquer the numbing isolation of homelessness.