Betty, an acclaimed, but washed-up painter, is commissioned to create an art piece for a prestigious museum. In order to regain the creative brilliance of the suffering artist, she isolates herself in a secluded house with one ambition: to induce depression.
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An intense and imaginative artist, revered Dutch painter Vincent van Gogh possesses undeniable talent, but he is plagued by mental problems and frustrations with failure. Supported by his brother, Theo, the tormented Van Gogh eventually leaves Holland for France, where he meets volatile fellow painter Paul Gauguin and struggles to find greater inspiration.
Suffering from a severe case of depression, toy company CEO Walter Black begins using a beaver hand puppet to help him open up to his family. With his father seemingly going insane, adolescent son Porter pushes for his parents to get a divorce.
A young man arrives at the last hometown of painter Vincent van Gogh to deliver the troubled artist's final letter and ends up investigating his final days there.
On the outside, Helen has it all – a loving family and a successful career – but when her suppressed mental illness resurfaces, the world crumbles around her. Crippled by depression, Helen finds solace through her friendship with Mathilda, a kindred spirit struggling with bipolar disorder.