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Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.

Claiming that he doesn't know his own past, a rich man enlists an ex-con with an odd bit of detective work. Gregory Arkadin says he can't remember anything before the late 1920s, and convict Guy Van Stratten is happy to take the job of exploring his new acquaintance's life story. Guy's research turns up stunning details about his employer's past, and as his work seems linked to untimely deaths, the mystery surrounding Mr. Arkadin deepens.

Mario, a worker in "lost and found" department, finds a suitcase with a dead baby inside.

Five men wake up in a locked-down warehouse with no memory of who they are. They are forced to figure out who is good and who is bad to stay alive.

A woman wakes up every day, remembering nothing as a result of a traumatic accident in her past. One day, new terrifying truths emerge that force her to question everyone around her.

Roy Freeman, an ex-homicide detective with a fractured memory, is forced to revisit a case he can't remember. As a man's life hangs in the balance on death row, Freeman must piece together the brutal evidence from a decade-old murder investigation, uncovering a sinister web of buried secrets and betrayals linking to his past. With only instincts to trust, he faces a chilling truth - sometimes, it's best to let sleeping dogs lie.