A New York City cop and an expert criminologist trying to solve a series of grisly deaths in which the victims have seemingly been maimed by feral animals discover a sinister connection between the crimes and an old legend.
The Freeling family move in with Diane's mother in an effort to escape the trauma and aftermath of Carol Anne's abduction by the Beast. But the Beast is not to be put off so easily and appears in a ghostly apparition as the Reverend Kane, a religious zealot responsible for the deaths of his many followers. His goal is simple - he wants the angelic Carol Anne.
Dr. Gorman is a millionaire adventurer, traveling the world in search of dangerous game. His bored, beautiful, much younger wife entertains herself in the arms of other men. In turn, Gorman uses his animals to kill these men. When a New York City zoo suggests a fundraising gala, Gorman sees a prime opportunity to dispatch the dashing Roger and anyone else who might cross him.
When an unknown disease wipes out most of the world’s population, a man with unique blood is isolated for study. Fearing for his wife’s safety, he breaks his quarantine – into a world overrun by monstrous Infected and a shadowy agency hunting them down.