Barry is a talented mechanic and family man whose life is torn apart on the eve of a zombie apocalypse. His sister, Brooke, is kidnapped by a sinister team of gas-mask wearing soldiers and experimented on by a psychotic doctor. While Brooke plans her escape Barry goes out on the road to find her and teams up with Benny, a fellow survivor – together they must arm themselves and prepare to battle their way through hordes of flesh-eating monsters in a harsh Australian bushland.
During an ever-growing epidemic of zombies that have risen from the dead, two Philadelphia SWAT team members, a traffic reporter, and his television-executive girlfriend seek refuge in a secluded shopping mall.
Two doctors find their graveyard shift inundated with townspeople ravaged by sores. Among the wounded is Cherry Darling, a dancer whose leg was ripped from her body. As the invalids quickly become enraged aggressors, Cherry and her ex-boyfriend El Wray lead a team of accidental warriors into the night.
In 1959, an alien experiment crashes to earth and infects a fraternity member. They freeze the body, but in the modern day, two geeks pledging a fraternity accidentally thaw the corpse, which proceeds to infect the campus with parasites that transform their hosts into killer zombies.
Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.