The passengers on the Night Bus have many different stories -- some are lovers, some have dark secrets, some are looking for a fight, others are just trying to get through the night.
On an empty road in the middle of the night, Shula stumbles across the body of her uncle. As funeral proceedings begin around them, she and her cousins bring to light the buried secrets of their middle-class Zambian family.
Bailey and Darla embark upon a misguided and mutually deceitful form of therapy, one in which they must drive across the country, re-enacting Darla's colorful history as a sex addict. As their true motivations for the road trip come to light, the unlikely pair force one another to confront their issues, discovering that there might actually be more to love than just sex.
Thomas is a meek man on the verge of a nervous breakdown. Despite his situation he decides to fake a work trip to go to Vallarta to confront Jero, a taxi driver who is sleeping with his wife.