Newly widowed Ruby feels elated by her husband's recent passing and is quick to move on with her life. Her grandson Tim, who she has tumultuous relationship with, attempts to get her to hold onto the good memories of his grandfather.
A tale of four generations of men, all of whom have had their offspring at a young age: a great-grandfather, a grandfather, a father in his twenties and a son who is about 7 years old. When the oldest member passes away, the trio heads out on the road together in the Southwest to search out an old family secret that connects to their past.
Rory is an ambitious entrepreneur who brings his American wife and kids to his native country, England, to explore new business opportunities. After abandoning the sanctuary of their safe American suburban surroundings, the family is plunged into the despair of an archaic '80s Britain and their unaffordable new life in an English manor house threatens to destroy the family.
Middle-aged widow Beatrice Hunsdorfer and her daughters Ruth and Matilda are struggling to survive in a society they barely understand. Beatrice dreams of opening an elegant tea room but does not have the wherewithal to achieve her lofty goal. Epileptic Ruth is a rebellious adolescent, while shy but highly intelligent and idealistic Matilda seeks solace in her pets and school projects, including one designed to show how small amounts of radium affect marigolds.
When lapsed Jew and former cardiologist Harry suddenly decides to spend his retirement as a pig farmer in Nazareth, Israel, the move deeply shocks his family and his new neighbours. Back in New York, Harry’s ex-wife Monica is trying to manage the lives of their adult children, Annabelle and David, as well as her own.
Michael is a 24-year-old who has cerebral palsy and long-term resident of the Carrigmore Residential Home for the Disabled, run by the formidable Eileen. His life is transformed when the maverick Rory O'Shea moves in.