A wager is made, a book of horror fiction is written. It becomes know as, "Frankenstein, or a Modern Prometheus", by Mary Shelley. Though what happens if fiction was fact? Can a soul be immortal. Is everlasting life worth such misery?
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Dr. Frankenstein and his monster both turn out to be alive after being attacked by an angry mob. The now-chastened scientist attempts to escape his past, but a former mentor forces him to assist with the creation of a new creature.
Frankenstein's unscrupulous colleague, Dr. Bohmer, plans to transplant Ygor's brain so he can rule the world using the monster's body, but the plan goes sour when he turns malevolent and goes on a rampage.
One of the sons of late Dr. Henry Frankenstein finds his father's ghoulish creation in a coma and revives him, only to find out the monster is controlled by Ygor who is bent on revenge.
The powers of good are pitted against the forces of evil as the Duc de Richelieu wrestles with the charming but deadly Satanist, Mocata, for the soul of his friend. Mocata has the knowledge and the power to summon the forces of darkness and, as the Duc de Richelieu and his friends remain within the protected pentacle, they are subjected to ever-increasing horror until thundering hooves herald the arrival of the Angel of Death.
After being resurrected by grave robbers, Larry Talbot searches for Dr. Frankenstein in the hopes of being cured of his lycanthropy. The mad scientist may turn out to be dead, but his monster is just waiting to be found…