The job of coroner has changed since the worldwide infection. Tommy Rossman isn't just a collector of the dead anymore. Now he comes to make sure you're actually dead. Or to help you get there.
A group of kids discover one of the drums containing a rotting corpse and release the 2-4-5 Trioxin gas into the air, causing the dead to once again rise from the grave and seek out brains.
Criminology student Chloe fakes her own death to break into a morgue, in order to retrieve a piece of evidence that ties her younger brother to a crime gone wrong. Once inside, she discovers that a sadistic coroner is using the corpses for his sick and twisted business, and when he realises that Chloe still has a pulse, a terrifying game of cat and mouse ensues.
Conducting clandestine experiments within the morgue at Miskatonic University, scientist Herbert West reveals to a fellow graduate student his groundbreaking work concerning the re-animation of fresh corpses.
Once again tampering with mother nature to disastrous results, Dr. Herbert West continues his research while serving time in a maximum security prison for his previous exploits. West's limited prison-cell experiments are suddenly interrupted by the arrival of a new prison doctor and the brother of the girl who suffered from West's experiments 13 years earlier.