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Nothing is what it seems when a twisted one-night stand spirals into a serial killer’s vicious murder spree.

Failed architect, engineer and vicious murderer Jack narrates the details of some of his most elaborately orchestrated crimes, each of them a towering piece of art that defines his life's work as a serial killer for twelve years.

Suffering from insomnia, disturbed loner Travis Bickle takes a job as a New York City cabbie, haunting the streets nightly, growing increasingly detached from reality as he dreams of cleaning up the filthy city.

In the future, medical technology has advanced to the point where people can buy artificial organs to extend their lives. But if they default on payments, an organization known as the Union sends agents to repossess the organs. Remy is one of the best agents in the business, but when he becomes the recipient of an artificial heart, he finds himself in the same dire straits as his many victims.

Yu Hong leaves her home village and starts university in Beijing, where she develops a consuming and compulsive relationship with another student. The student riots from 1989 then ensue and take a toll on their lives.

In late 1960s New York City, fed up with monotonous college life and police repression, free-spirited Fritz, an impenitent seducer and unrestrained party-animal, decides to explore the world. And just like that, as he flees NYC, heading to San Francisco, Fritz embarks on an endless adventure of illumination. Immersed in a world surrounded by drugs and sex, Fritz participates in mad orgies, brings about a revolution, incites mass urban riots, and crosses paths with drug-addled Nazi bikers.