Leah, 10, has terrible nightmares. Her mother seems distant somehow, lost in her thoughts. A small, nightly visitor brings Leah comfort, but soon Leah will realize that her little visitor offers knowledge that might be very, very dangerous.
When Christy discovers her 10-year-old daughter Anna has a rare, incurable disease, she becomes a ferocious advocate for her daughter’s healing as she searches for a solution. After Anna has a freak accident and falls three stories, a miracle unfolds in the wake of her dramatic rescue that leaves medical specialists mystified, her family restored and their community inspired.
As Constance (Natasha Richardson) and Nina (Toni Collette) gather at the deathbed of their mother, Ann (Vanessa Redgrave), they learn for the first time that their mother lived an entire other lifetime during one evening 50 years ago. In vivid flashbacks, the young Ann (Claire Daines) spends one night with a man named Harris (Patrick Wilson), who was the love of her life.
In the middle of a routine patrol, officer Daniel Carter happens upon a blood-soaked figure limping down a deserted stretch of road. He rushes the young man to a nearby rural hospital staffed by a skeleton crew, only to discover that patients and personnel are transforming into something inhuman. As the horror intensifies, Carter leads the other survivors on a hellish voyage into the subterranean depths of the hospital in a desperate bid to end the nightmare before it's too late.