After a mysterious bout of amnesia, a beloved children’s television host struggles to piece together his fractured memories, only to find his once-cheerful puppet co-stars behaving with sinister intent. As reality unravels, the line between performance and nightmare begins to blur.
Wisecracking reporter Carl Kolchak investigates a string of murders in Las Vegas and suspects the culprit is a vampire. His editor thinks he's crazy and the police think he's a nuisance, so Kolchak takes matters into his own hands.
After going their separate ways, Scooby-Doo, Shaggy, Velma, Daphne, and Fred reunite to investigate the ghost of Moonscar the pirate on a haunted bayou island, but it turns out the swashbuckler's spirit isn't the only creepy character on the island. The sleuths also meet up with cat creatures and zombies... and it looks like for the first time in their lives, these ghouls might actually be real.