16-year old Rhiannon falls in love with a mysterious spirit named “A” that inhabits a different body every day. Feeling an unmatched connection, Rhiannon and “A” work each day to find each other, not knowing what the next day will bring.
Elizabeth, a charming morning show news anchor, seeks advice from her dog's therapist after a breakup. Tara, a spunky barista, dreams of a life beyond the coffee shop. Awkward Garrett pines for Tara while trying to keep his adopt-a-dog business afloat. Dax is a man-child and leader of the aspiring rock band Frunk. Grace and Kurt anxiously await the arrival of their adoptive daughter, Amelia. Walter, an aging, lonely widower, loses his dog Mabel when she runs off. The beloved canines in their lives soon start to influence their careers, friendships, and romantic relationships in funny and unexpected ways.
After a disastrous first date, wild-child Nicole and socially-anxious Max vow to lose each other’s numbers until they learn that their dogs found a love match, and now puppies are on the way! The hilariously mismatched Nicole and Max are forced to become responsible co-parents, but may end up finding love themselves.
Workaholic Thomas Johnson dies in an auto accident and reincarnates as a dog. Remembering some of his previous being, he returns to his wife and son to protect them from the man who caused his accident. But, as time goes by, his memories return, and Thomas realizes he wasn't such a good husband and father.