In 1968, Frank Lucas (drug dealer) is the right-hand man of Harlem gangster Bumpy Johnson. When Johnson dies of a heart attack, Lucas takes control of the Harlem crime scene.
Ace is an impressionable young man working for a dry cleaning business. His friend, drug dealer Mitch, goes to prison. In an unrelated incident, he finds some cocaine in a pants pocket. Soon, Ace finds himself dealing cocaine for Lulu. Via lucky breaks and solid interpersonal skills, Ace moves to the top of the Harlem drug world. Of course, unfaithful employees and/or rivals conspire to bring about Ace's fall.
In New York, racist Capt. Stanley White becomes obsessed with destroying a Chinese-American drug ring run by Joey Tai, an up-and-coming young gangster as ambitious as he is ruthless. While pursuing an unauthorized investigation, White grows increasingly willing to violate police protocol, resorting to progressively violent measures -- even as his concerned wife, Connie, and his superiors beg him to consider the consequences of his actions.
Undercover Las Vegas police officer Vincent Downs, who has a lot of enemies, is caught in a high stakes web of corrupt cops and the mob-controlled casino underground. When a heist goes wrong, a crew of homicidal gangsters kidnap Downs’ teenage son T. In one sleepless night, Downs will have to rescue his son, evade an internal affairs investigation, and bring the kidnappers to justice.
The story of how George Jung, together with the Medellín Cartel led by Pablo Escobar, established the billion-dollar cocaine empire in the United States in the 1970s.