A gangster, Nino, is in the Cash Money Brothers, making a million dollars every week selling crack. A cop, Scotty, discovers that the only way to infiltrate the gang is to become a dealer himself.
Loosely based on the criminal career of Frank Lucas, a gangster from La Grange, North Carolina, who smuggled heroin into the United States on American service planes returning from the Vietnam War, before being detained by a task force led by Newark Detective Richie Roberts.
Based on the true life experiences of poet Jimmy Santiago Baca, the film focuses on half-brothers Paco and Cruz, and their bi-racial cousin Miklo. It opens in 1972, as the three are members of an East L.A. gang known as the "Vatos Locos", and the story focuses on how a violent crime and the influence of narcotics alter their lives. Miklo is incarcerated and sent to San Quentin, where he makes a "home" for himself. Cruz becomes an exceptional artist, but a heroin addiction overcomes him with tragic results. Paco becomes a cop and an enemy to his "carnal", Miklo.