A terminally ill man and his teenage daughter embark on a road trip from California to New Orleans for his 20th college reunion. While there, he secretly hopes she can reunite with the mother who left them long ago.
Dr. Malcolm Sayer, a shy research physician, uses an experimental drug to "awaken" the catatonic victims of a rare disease. Leonard is the first patient to receive the controversial treatment. His awakening, filled with awe and enthusiasm, proves a rebirth for Sayer too, as the exuberant patient reveals life's simple but unutterably sweet pleasures to the introverted doctor.
Young musician Zach Sobiech discovers his cancer has spread, leaving him just a few months to live. With limited time, he follows his dream and makes an album, unaware that it will soon be a viral music phenomenon.