A man risks experimenting with a cataleptic effects pill that seeks faking his death and then returned from the grave to take its own life insurance. But something happens and things do not go as he planned.
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In 1840s London, Dr. Thomas Bolton [Boris Karloff] dares to dream the unthinkable: experimenting with anesthesia gases to make surgery pain-free. While doing so, his demonstration before a panel of his peers ends in a horrific mishap with his patient awakening under the knife; he is forced to leave his position in disgrace. To complicate matters, he becomes addicted to his own chemical experiments and gets involved with a criminal gang led by Black Ben [Francis de Wolff], and a ruthless killer Resurrection Joe [Christopher Lee]. Unfortunately, this shady partnership leads Dr. Bolton to further ruin, culminating in his unwitting participation in murder — for which he becomes the first victim of a blackmail scheme.