A pair of friendly coworkers at a rental video store accidentally become murderers. Borrowing a station wagon, they flee with no particular destination in mind.
While Native American Wolf is being pursued by the FBI for having taken the law into his own hands, when his mother was raped and killed on their reservation he crosses paths with Cash, a down and out musician who is coping with the end of his marriage. An unlikely friendship develops, as they ride together towards the Teton mountain range, where Wolf will spread his mothers ashes.
In a suburban landscape, the lives of several families interlace with loss, despair and personal crisis. Esther Gold has lost focus on all but caring for her comatose son, Paul, and neglects her daughter and husband. Lawyer Jim Train is devoted to his career, not his family. Helen Christianson wants to find a new spark in life, while Annette Jennings tries to rebuild hers.