Margherita nicknamed Fornarina is Raphael's mistress. Beatrice, a noblewoman who is also in love with the famous painter tries to get her out of the way, by having her wrongly accused of the murder of a loan shark, whom she has in reality killed herself.
Antonio, a former variety actor, keeps his daughter in an excellent boarding school by organizing small scams with his friend and colleague Felice. Commissioner Malvasia good-naturedly persecuted him. When their respective unsuspecting children fall in love, the two fathers make peace.
A vicious serial sex killer is on the loose, and landscape gardener and shop-window outfitter Loris is the prime suspect, thanks to his unfortunate habit of getting caught in compromising situations (for which there is always a totally innocent explanation that the police fail to spot). Undercover policewoman Jessica is assigned by eccentric police psychologist Taccone to follow Loris.
65 year old doctor Pierfrancesco works as a night-shift medical guard. He’s a grumpy man, full of aches and pains and is very rough with his patients. One night, he’s involved in a road collision with 30 year old delivery man Mario. While uninjured, Mario's bicycle is destroyed, and Pierfrancesco's sciatica flares up, making it impossible for him to drive. With both of their jobs in jeopardy, the doctor has an idea that could help them both: “remotely guided” by Pierfrancesco via wireless headset, Mario will visit his patients, and they’ll also carry out Mario’s delivery in Pierfrancesco’s car. After a range of daring (mis)adventures, they will learn to support each other, and the night will end with their lives both changed for the better.