In Rome, during the early 30s, a con artist played by Totò impersonates dr. Biagio Tanzarella, Benito Mussolini's personal physician in order to blackmail Ernesto, an unfaithful husband.
65 year old doctor Pierfrancesco works as a night-shift medical guard. He’s a grumpy man, full of aches and pains and is very rough with his patients. One night, he’s involved in a road collision with 30 year old delivery man Mario. While uninjured, Mario's bicycle is destroyed, and Pierfrancesco's sciatica flares up, making it impossible for him to drive. With both of their jobs in jeopardy, the doctor has an idea that could help them both: “remotely guided” by Pierfrancesco via wireless headset, Mario will visit his patients, and they’ll also carry out Mario’s delivery in Pierfrancesco’s car. After a range of daring (mis)adventures, they will learn to support each other, and the night will end with their lives both changed for the better.
Benito Mussolini resurfaces in Rome 72 years after his death, as if not a single day had passed. Finding a country still full of problems, both old and new, his firebrand rhetoric wins him once again the hearts and minds of millions of Italians — who see him as a wacky reenactor who speaks inconvenient truths to power.
In 18th-century Rome, impish aristocrat Onofrio del Grillo amuses himself by playing pranks on all sorts of people — his reactionary family and fellow nobles, the poors, the French occupiers trying to modernize society, and even the Pope himself.
A medicine man is sent looking for the son of his tribal king, and brings back an American golfer and a host of goons intent on keeping him in the golf tournament.