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After a chaotic night of rioting in a marginal suburb of Paris, three young friends, Vinz, Hubert and Saïd, wander around unoccupied waiting for news about the state of health of a mutual friend who has been seriously injured when confronting the police.

Three friends growing up in South Central Los Angeles navigate a neighborhood plagued by violence, unemployment, and crime, each responding differently to the harsh realities of street life. As tragedy strikes close to home, their friendship, choices, and hopes for a better future are put to the ultimate test.

Ace is an impressionable young man working for a dry cleaning business. His friend, drug dealer Mitch, goes to prison. In an unrelated incident, he finds some cocaine in a pants pocket. Soon, Ace finds himself dealing cocaine for Lulu. Via lucky breaks and solid interpersonal skills, Ace moves to the top of the Harlem drug world. Of course, unfaithful employees and/or rivals conspire to bring about Ace's fall.

Based on the true life experiences of poet Jimmy Santiago Baca, the film focuses on half-brothers Paco and Cruz, and their bi-racial cousin Miklo. It opens in 1972, as the three are members of an East L.A. gang known as the "Vatos Locos", and the story focuses on how a violent crime and the influence of narcotics alter their lives. Miklo is incarcerated and sent to San Quentin, where he makes a "home" for himself. Cruz becomes an exceptional artist, but a heroin addiction overcomes him with tragic results. Paco becomes a cop and an enemy to his "carnal", Miklo.

In a ghetto where religion and drug trafficking rub shoulders, Dounia has a lust for power and success. Supported by Maimouna, her best friend, she decides to follow in the footsteps of Rebecca, a respected dealer. But her encounter with Djigui, a young, disturbingly sensual dancer, throws her off course.

Noumouké, from the suburb of Paris, is about to decide which brother's foot steps to follow - the lawyer student Soulaymaan or the gangster Demba.