A truck-stop waitress, determined to make a better life for her young children after being abandoned by her husband, leaves hash-slinging behind her to embark on a new career as a trucker in the rig her late father used to drive.
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Joe and Paul Fabrini are Wildcat, or independent, truck drivers who have their own small one-truck business. The Fabrini boys constantly battle distributors, rivals and loan collectors, while trying to make a success of their transport company.
Nick Garcos comes back from his tour of duty in World War II planning to settle down with his girlfriend, Polly Faber. He learns, however, that his father was recently beaten and burglarized by mob-connected trucker Mike Figlia, and Nick resolves to get even. He partners with prostitute Rica, and together they go after Mike, all the while getting pulled further into the local crime underworld.
Thomas Montgomery, a married father of two young daughters, gets seduced by the world of online gambling and chat rooms where a virtual romance and sexual obsession ultimately leads to the murder of an innocent man.
Christabel Caine has the face of angel and the heart of a swamp rat. She'll step on anyone to get what she wants, including her own family. A master of manipulation, she covertly breaks off the engagement of her trusting cousin, Donna, to her fabulously wealthy beau, Curtis Carey. Once married to Curtis herself, Christabel continues her affair with novelist Nick Bradley, who knows she's evil, but loves her anyway.
A truck driver has been forced to smuggle illicit cargo to save her brother from a deadly prison gang. With FBI operatives hot on her trail, Sally's conscience is challenged when the final package turns out to be a teenage girl.
Taking a break from their dreary lives, close friends Thelma and Louise embark on a short weekend trip that ends in unforeseen incriminating circumstances. As fugitives, both women rediscover the strength of their bond and their newfound resilience.