For years, Blade has fought against the vampires in the cover of the night. But now, after falling into the crosshairs of the FBI, he is forced out into the daylight, where he is driven to join forces with a clan of human vampire hunters he never knew existed—The Nightstalkers. Together with Abigail and Hannibal, two deftly trained Nightstalkers, Blade follows a trail of blood to the ancient creature that is also hunting him—the original vampire, Dracula.
When several young girls are found dead, left hideously aged and void of blood, Dr. Marcus suspects vampirism. He enlists the help of the Vampire Hunter. Mysterious and powerful, Kronos has dedicated his life to destroying the evil pestilence. Once a victim of its diabolical depravity, he knows the vampire's strengths and weaknesses as well as the extreme dangers attached to confronting the potent forces of darkness.
In an alternate world, humanity and vampires have warred for centuries. After the last Vampire War, the veteran Warrior Priest lives in obscurity with other humans inside one of the Church's walled cities. When the Priest's niece is kidnapped by vampires, the Priest breaks his vows to hunt them down. He is accompanied by the niece's boyfriend, who is a wasteland sheriff, and a former Warrior Priestess.
The church enlists a team of vampire-hunters to hunt down and destroy a group of vampires searching for an ancient relic that will allow them to exist in sunlight.