After a deadly storm, Tom and Jerry find themselves stranded on an unknown island ruled by the evil Wizard of Oz. As they try to find their way back home, they worry for their master Dorothy's safety.
Jasper is given an ultimatum by his master: break one more thing and you're out. Rodent Jerry does his best to make sure that his tormentor "gets the boot".
When Toaster and the gang spark friendships with the playful animals at the veterinary hospital, they soon discover their new pals are about to be sent to a testing laboratory.
The popular cartoon cat and mouse are thrown into a feature film. The story has the twosome trying to help an orphan girl who is being berated and exploited by a greedy guardian.