Mitsuki Kimijima

Uchida Mayu is a high school student in a peaceful town near Tokyo. She suffers from violence from her stepfather and plans to run away to her uncle's home in Tokyo. As she is about to board the last bus to Tokyo, a terrible looking old person causes her to miss the bus. She attempts to walk across a ridge. Meanwhile, Mayu's uncle Uchida Kazuki is a freelancer writer. He chases after the hideous monster Yoshie who attacks people. Kazuki receives a phone call that his niece Mayu ran away. He begins a search for her and finds her cellphone on a mountain path. He sees Yoshie's picture on her cellphone.

Freelancer reporter, Kazuki Uchida, knocks down the creepy monster Yoshie, but during that time Hatakeyama is sacrificed. While chasing after the mystery of Yoshie, Kazuki visits a hospital. She visits a man, based on information left by Hatakeyama. Meanwhile, Hatakeyama’s daughter Saori receives a letter from her father asking her to send the thing that he left for her.

In an alternative feudal Japan, a strange disease that only affects males caused a massive population reduction, leaving females to fill the vacant jobs, therefore changing the social structure. Now, 80 years after the initial outbreak with a 1:4 male:female ratio, Japan is a completely matriarchal society. Females hold all important political positions, and males are their consorts. Only the most powerful female—head of Tokugawa shogunate—may keep a harem of handsome and unproductive males, known as "Ōoku".

A medical drama following rookie emergency physicians, paramedics, and police officers as they clash with bitter realities and social issues while striving to save lives on the front lines.