Cole Thornton, a gunfighter for hire, joins forces with an old friend, Sheriff J.P. Harrah. Together with a fighter and a gambler, they help a rancher and his family fight a rival rancher that is trying to steal their water.
Texas Ranger Jake Cutter arrests gambler Paul Regret, but soon finds himself teamed with his prisoner in an undercover effort to defeat a band of renegade arms merchants and thieves known as Comancheros.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
The only business in the Wild West town of Jericho that corrupt sheriff Alex Flood doesn't control behind the scenes is the stagecoach owned by tough-willed widow Molly Lang and her right-hand man, Hickman. Former marshal Dolan, recently hired by Lang and Hickman as a driver, wants to stay out of the mess, but when he sees Flood's henchman Yarbrough assault Lang, he steps up to fight the corruption.