15-year-old Ben Tennyson chooses to once again put on the Omnitrix and discovers that it has recalibrated and can now transform him into 10 brand-new aliens. Joined by his super-powered cousin Gwen Tennyson and his equally powerful former enemy Kevin Levin, Ben is on a mission to find his missing Grandpa Max.
When 10-year-old Ben Tennyson discovers a mysterious device, he gains the power to change into ten different alien heroes, each with uniquely awesome powers. With such abilities at his disposal, Ben realizes a greater responsibility to help others and stop evildoers, but that doesn't mean he's above a little superpowered mischief now and then.
An insecure but courageous and intelligent teen named Peter Parker, a new student of Midtown High, is bitten by a radioactive spider and given powers. He becomes a hero named Spider-Man after the death of his uncle and he must adapt to this new way of life.
With his secret identity now revealed to the world, Ben Tennyson continues to fight evil as a superhero with the help of the newly acquired Ultimatrix.
A year after the events that took place during the "Final Battle" and equipped with an all-new completed Omnitrix, 16-year-old Ben Tennyson has to face new enemies.