Cha Yo-Han—an arrogant but genius doctor of anesthesiology—and Kang Shi-Young—a smart, warm resident of anesthesiology—work together to help people with mysterious cases of acute or chronic pain.
The story takes place at the beginning of the 19th century. Goo Hae-Ryung is a historian who tries to fight gender stereotypes as her work is often looked down on. She meets Prince Yi Rim.
Based on a novel of the same name, it tells the record of a royal court romance between the King of Joseon who believes his duty is to his country first above love, and a court lady who wants to protect the life she has chosen.