When her Alzheimer's disease-suffering mother, Ruth, wanders into a blizzard on Christmas Eve, Bridget Ertz travels back to her hometown to help her brother convince their father to put Ruth in a nursing home and face the end of their life-long love affair.
Isabelle, a geneticist recovering from a toxic marriage, is raising her only daughter, Zoe, with her contentious ex-husband. Zoe means everything to her mother and so when tragedy strikes the fractured family, Isabelle travels to Russia in seeking the help of a world-renowned fertility physician who Isabelle believes can help bring back her little girl.
A poor, struggling South Carolinian mother and daughter face painful choices with their resolve and pride. Bone, the eldest daughter, and Anney her tired mother, grow both closer and farther apart: Anney sees Glen as her last chance.
In a suburban landscape, the lives of several families interlace with loss, despair and personal crisis. Esther Gold has lost focus on all but caring for her comatose son, Paul, and neglects her daughter and husband. Lawyer Jim Train is devoted to his career, not his family. Helen Christianson wants to find a new spark in life, while Annette Jennings tries to rebuild hers.
In New York City, the lives of a lawyer, an actuary, a house-cleaner, a professor, and the people around them intersect as they ponder order and happiness in the face of life's cold unpredictability.