A young woman with psychokinetic powers breaks out of a Louisiana asylum and makes her way to New Orleans, where she falls into the city’s netherworld of misfits and miscreants.
After an accident, acclaimed novelist Paul Sheldon is rescued by a nurse who claims to be his biggest fan. Her obsession takes a dark turn when she holds him captive in her remote Colorado home and forces him to write back to life the popular literary character he killed off.
Residents of a coastal town learn, with deadly consequences, the secret shared by the two mysterious women who have sought refuge at a local boarding house, the Byzantium.