The film details the adventures and misadventures of a group of patients with OCD, all of whom have an appointment with their doctor at the same time. However, the doctor is delayed by a flight, forcing them to deal with each other's quirks and compulsions.
When a woman is admitted by her daughters to a psychiatric clinic for her carefree ways, an expert must judge if she is ill or simply wants to enjoy life.
Batman and Nightwing are forced to team with the Joker's sometimes-girlfriend Harley Quinn to stop a global threat brought about by Poison Ivy and Jason Woodrue, the Floronic Man.
A psychiatrist with intense acrophobia (fear of heights) goes to work for a mental institution run by doctors who appear to be crazier than their patients, and have secrets that they are willing to commit murder to keep.