When a blind woman, Gina (Blake Lively), regains her sight after a corneal implant, she begins to discover the previously unseen and disturbing details about her life with her husband James (Jason Clarke).
Dr. Steven Murphy is a renowned cardiovascular surgeon who presides over a spotless household with his wife and two children. Lurking at the margins of his idyllic suburban existence is Martin, a fatherless teen who insinuates himself into the doctor's life in gradually unsettling ways.
While undergoing heart surgery, a man experiences a phenomenon called ‘anesthetic awareness’, which leaves him awake but paralyzed throughout the operation. As various obstacles present themselves, his wife must make life-altering decisions while wrestling with her own personal drama.
Dr. Martin Blake, who has spent his life looking for respect, meets an 18-year-old patient named Diane, suffering from a kidney infection, and gets a much-needed boost of self-esteem. However, when her health starts improving, Martin fears losing her, so he begins tampering with her treatment, keeping Diane sick and in the hospital right next to him.
Not long after they cross paths at an art gallery, architect Ray Reardon and hypnotically sensual Lena are married with children. But as strange incidents occur, Ray begins to realize he may not really know the woman he married.