The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.
A horror anthology containing three stories: a female college professor is aggressively pursued by one of her students; a prudish brunette determines that her free-spirited blonde sister is evil; and a woman's night turns upside down after she purchases an ancient Zuni fetish doll.
Five train passengers are joined by a mysterious fortuneteller who offers to read Tarot. A quintet of stories unfold: an architect returns to his ancestral home to find a vengeful werewolf; a doctor suspects his new wife is a vampire; an intelligent vine takes over a house; a jazz musician plagiarises music from a voodoo ceremony; and a pompous art critic is pursued by a disembodied hand.
A series of down-on-their-luck individuals enter the decrepit and spine-chilling Rialto theater, only to have their deepest and darkest fears brought to life on the silver screen by The Projectionist – a mysterious, ghostly figure who holds the nightmarish futures of all who attend his screenings.