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A poor, struggling South Carolinian mother and daughter face painful choices with their resolve and pride. Bone, the eldest daughter, and Anney her tired mother, grow both closer and farther apart: Anney sees Glen as her last chance.

In a suburban landscape, the lives of several families interlace with loss, despair and personal crisis. Esther Gold has lost focus on all but caring for her comatose son, Paul, and neglects her daughter and husband. Lawyer Jim Train is devoted to his career, not his family. Helen Christianson wants to find a new spark in life, while Annette Jennings tries to rebuild hers.

Years after her son's suicide, a woman longs to confront both the past and a friend of his who took his business idea.

Nola grew up living in a van with her father, Clint—two nomads against the world. When tragedy strikes, Nola must confront the reality of life on the road alone, learning to own her grief, her past, and her new destination.

Isabelle, a geneticist recovering from a toxic marriage, is raising her only daughter, Zoe, with her contentious ex-husband. Zoe means everything to her mother and so when tragedy strikes the fractured family, Isabelle travels to Russia in seeking the help of a world-renowned fertility physician who Isabelle believes can help bring back her little girl.

A jazz musician seeks refuge from a lynch mob on a remote island, where he meets a hostile game warden and the young object of his attentions.