John Quincy Archibald is a father and husband whose son is diagnosed with an enlarged heart and then finds out he cannot receive a transplant because HMO insurance will not cover it. Therefore, he decides to take a hospital full of patients hostage until the hospital puts his son's name on the donor's list.
Jerry Shaw and Rachel Holloman are two strangers whose lives are suddenly thrown into turmoil by a mysterious woman they have never met. Threatening their lives and family, the unseen caller uses everyday technology to control their actions and push them into increasing danger. As events escalate, Jerry and Rachel become the country's most-wanted fugitives and must figure out what is happening to them.