A motley crew of young rebellious aliens commandeer an old Starfleet ship and must figure out how to work together while navigating a greater galaxy, in search for a better future. These six young outcasts know nothing about the ship they have commandeered, but over the course of their adventures together, they will each be introduced to Starfleet and the ideals it represents.
Jimmy Neutron is the smartest kid in town. As a genius, Jimmy thinks most things can be solved with the invention of a new gizmo. But Jimmy usually takes the easy way out, and his backfiring gadgets result in comedic adventures.
Leo is an ordinary teenager who has moved into a high-tech "smart'' house with his mother, inventor stepfather and Eddy, the computer that runs the house. Leo's life becomes less ordinary when, one day, he discovers a secret underground lab that houses three experiments: superhuman teenagers. The trio -- Adam, the strong one, Bree, the fast one and Chase, the smart one -- convinces Leo and his parents to let them leave their lab and join Leo at school, where they try to fit in while having to manage their unpredictable bionic strengths. As Leo figures out a way to keep his new pals' bionic abilities a secret, they help him build self-confidence.