Ramona is a little girl with a very big imagination and a nose for mischief. Her playful antics keep everyone in her loving family on their toes, including her older sister Beezus, who's just trying to survive her first year of high school. Through all the ups and downs of childhood, Ramona and Beezus learn that anything's possible when you believe in yourself and rely on each other.
A childless couple bury a box in their backyard, containing all of their wishes for an infant. Soon, a child is born, though Timothy Green is not all that he appears.
History -- make that high school -- may repeat itself when Marni learns that Joanna, the mean girl from her past, is set to be her sister-in-law. Before the wedding bells toll, Marni must show her brother that a tiger doesn't change its stripes. On Marni's side is her mother, while Joanna's backed by her wealthy aunt.