Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.
Years after a mysterious plague has devastated the planet and turned most of humanity into blood-hungry creatures, a rogue drifter on a vengeful hunt stumbles across a band of survivors in an abandoned police station and reluctantly agrees to try to help them defend themselves and escape to the sanctuary they so desperately need.
Branded a traitor by her countrymen, French national Marie DuJardin is rescued by American soldiers on one condition: to survive, she must lead them to a cache of gold - before the Nazis return to claim it for themselves.