A man (Sharlto Copley) wakes up in a large pit full of dead bodies and does not remember how he got there. In a panic he cries for help before a woman throws a rope down into the pit, allowing him to climb and escape.
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In a post-apocalyptic world, a virus has transformed humans into violently deranged cannibals. A bereaved mother has lost everything and takes refuge in an isolated mountain cabin, until a desperate wounded stranger arrives with a story of hope.
In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly and the son of a famous virus expert who may hold the key to the Army of the 12 Monkeys; thought to be responsible for unleashing the killer disease.
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After fleeing his psychotic father, a young teen and his mom seek refuge in a remote farmhouse, only to face a pack of ferocious dogs and the sinister spirits that haunt the property.