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Four tales unfold in Wes Anderson's anthology of short films adapted from Roald Dahl's beloved stories, "The Wonderful Story of Henry Sugar", "The Swan", "The Rat Catcher", and "Poison."

On a Tuesday night, five couples have separate sexual adventures. Matt and Kris, friends for years, want to have an only-once, no-strings good time. Abby and Andrew, married, celebrate his birthday, but it's marred by angst and miscommunication. Mia and Eric are exes, making sure they are over each other. Jaime and Ken work together and this is a first date. Inez and Gord invite his roommate, Dave, to join them. By the time each couple has gone through a prelude, foreplay, sex, an interlude, orgasm, and afterglow, they've answered basic questions: can sex be anonymous, are we bored, is our marriage really finished, does anyone tell the truth, and how do we make someone happy?

Two romantic burnouts, Jane and Will, are immediately drawn to each other at a mutual friend’s wedding. After a disastrous hookup in the coatroom, the two spend the next 24 hours together, trading candid confessions of messy histories and heartbreak, on the off chance that this fling might be the real thing.

Cynthia Rand is a buttoned-up New Yorker married to a brilliant professor 25 years her senior. She begins feeling the effects of her husband’s advancing age on their relationship, just as her world is turned upside down by the arrival of sharp but chronically underachieving security guard Stan Olszewski in this smart rom-com that reunites Bacon and Sedgwick on screen for the first time in 20 years.

Seven mini-stories of adultery: a widow misbehaves at her husband's funeral, a wife turns to streetwalking for revenge, a prudish girl surprises, a neglected wife vies for her husband's attention, a fight over a dress, a death pact, and a detective revealed as a jealous husband's spy.

Three friends begin a dangerous three-way relationship that spirals out of control, leading to dire consequences that haunt them ten years later.