A young woman with no strong religious beliefs, Frankie Paige begins having strange and violent experiences, showing signs of the wounds that Jesus received when crucified. When the Vatican gets word of Frankie's situation, a high-ranking cardinal requests that the Rev. Andrew Kiernan investigate her case. Soon Kiernan realizes that very sinister forces are at work, and tries to rescue Frankie from the entity that is plaguing her.
Father Gabriele Amorth, Chief Exorcist of the Vatican, investigates a young boy's terrifying possession and ends up uncovering a centuries-old conspiracy the Vatican has desperately tried to keep hidden.
Vice detective Bob Hightower finds his ex-wife murdered and daughter kidnapped by a cult. Frustrated by the botched official investigations, he quits the force and infiltrates the cult to hunt down the leader with the help of the cult’s only female victim escapee, Case Hardin.
A single mom is raped by an invisible force. Her psychiatrist believes the experience stems from childhood trauma, while she knows something supernatural is at play.