In just three days, Gabriela feels that her ideal marriage and her flourishing business are in grave danger, due to the sudden and fearful reappearance in her life of Felisa, a former high school classmate, who carries the history of bringing bad luck and misfortune with her.
Laura has been with Antonio all her life and, just when she begins to wonder if that is really the life she wants, Sergio and Siena cross paths in their lives. Sergio is a former high school classmate and Siena, his millennial girlfriend who arrives to revolutionize everyone's lives. Laura, Raquel and Cris, close friends for years, convince their respective husbands to play a game that Siena proposes to them: the game of keys. The game consists of everyone putting their keys in a bowl. At random, each one chooses some keys and he must go to spend the night with the owner of the keys. This game will revolutionize the group of friends and their lives. It will make them discover who they are and what they really want.
Luisa cheats on Guillermo with Sebastian, who cheats on Ximena. When Luisa goes missing after both couples return from a double date night, the whole house of cards starts tumbling down.