In a town overrun with zombies, vampires, and a melting mad scientist with plans for an impending alien invasion, it's up to a select few to try and keep order.
Wisecracking reporter Carl Kolchak investigates a string of murders in Las Vegas and suspects the culprit is a vampire. His editor thinks he's crazy and the police think he's a nuisance, so Kolchak takes matters into his own hands.
A man and wife are terrorized by Mad Scientist Dr. Callistratus who was executed but has returned to life with a heart transplant. Along with his crippled assistant Carl, the 'anemic' Mad Scientist, believed to be a vampire, conducts blood deficiency research on the inmates of a prison hospital for the criminally insane to sustain his return to life.
A crack test pilot lands to find the planet has been devastated by unknown forces. There are a few survivors, so he organizes them in a plan to ward off control by a group of killer robots.
In a massive, mysterious chamber, fifty strangers awaken to find themselves trapped with no memory of how they got there. Organized in an inward-facing circle and unable to move, they quickly learn that every two minutes, one of them must die…executed by a strange device in the center of the room.