After a frantic suicide attempt, Veronika awakens inside a mysterious mental asylum. Under the supervision of an unorthodox psychiatrist who specializes in controversial treatment, Veronika learns that she has only weeks to live.
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Vincent Bruce, a war veteran, begins working as an occupational therapist at Poplar Lodge, a private psychiatric facility for wealthy people where he meets Lilith Arthur, a charming young woman suffering from schizophrenia, whose fragile beauty captivates all who meet her.
A woman becomes very curious about one of her psychiatrist husband's inmates, a man who was found guilty in the murder and disfigurement of his former wife.
Virginia Cunningham is confused upon finding herself in a mental hospital, with no memory of her arrival at the institution. Tormented by delusions and unable to even recognize her husband, Robert, she is treated by Dr. Mark Kik, who is determined to get to the root of her mental illness. As her treatment progresses, flashbacks depict events in Virginia's life that may have contributed to her instability.
Zach Riley is a psychiatrist, who leaves a job at a prestigious university, to take up a job at the privately run mental institution, Millwood. What he doesn't reveal at the time of his appointment is that this was the very place where his novelist father, T.L. Pierson, spent many years of his life.
In New York City, the lives of a lawyer, an actuary, a house-cleaner, a professor, and the people around them intersect as they ponder order and happiness in the face of life's cold unpredictability.