Sofia discovers that her husband has links to drug trafficking and decides to cooperate with the DEA. Threatened, she must go to Spain with her daughter to start a new life.
In this new era, Catalina, now head of the DEA in Colombia, has a new challenge: to track down a criminal organization that is trafficking a new synthetic drug. What she ignores is that her daughter is part of the Cartel that traffics them and that Yésica, her worst enemy, is infiltrated in the DEA.
Pablo is a man with a natural ability for business. Early in his life, Pablo is introduced to the business of cocaine and the power it yields. A young life of crime lands Pablo in and out of jail as he builds his criminal empire. Pablo expands his power through politics but it is not long before his conflicts as a Congressman and a drug lord collide. Pablo has his enemies executed, but not before the United States activates its own war on the Medellin cartel.
A woman starts an affair with a male escort to get revenge on her controlling husband, but the plan spirals into a dangerous fight for survival when it leads to a crime scene with her husband missing and her lover on the run.
Tommy Egan leaves New York behind and plans to take on Chicago, using his outsider status to break all the local rules and rewrite them on his quest to become the biggest drug dealer in the city.