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When petty criminal Earl Hickey wins the lottery, he sets off on a quest to repair his questionable karma.

One day while returning home to stay with his widowed twin sister and her daughter, Kevin Finn, a self-centered man whose life brings him more trouble than he bargained for, is recruited by a celestial being named Yvette, who enlists Kevin with a new purpose in his life, which is to save the world.

Samantha Newly has been a bad, bad girl. But thanks to an 8-day coma, she can't remember a thing. Fortunately her best friend Andrea is by her side with a cocktail and the 4-1-1 on every dirty deed. But the more Sam pieces together her past, the less she likes her old self. Maybe this is a chance to start over and do it all again.

Joan Girardi has begun acting a little strange since her family moved to the city of Arcadia. No one knows that various people keep introducing themselves as God, and then giving the teenager specific directions to do things. Unsure of what God wants, and if she's even sane, Joan tentatively begins to follow God's cryptic directives, all the while trying to retain a "normal" teen-aged existence.

Monica, an angel, is tasked with bringing guidance and messages from God to various people who are at a crossroads in their lives.

A probationary angel is sent back to Earth to team up with an ex-cop and help people.