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Tells the parallel stories of nine-year-old Carlitos and his mother, Rosario. In the hopes of providing a better life for her son, Rosario works illegally in the U.S. while her mother cares for Carlitos back in Mexico.

In a suburban landscape, the lives of several families interlace with loss, despair and personal crisis. Esther Gold has lost focus on all but caring for her comatose son, Paul, and neglects her daughter and husband. Lawyer Jim Train is devoted to his career, not his family. Helen Christianson wants to find a new spark in life, while Annette Jennings tries to rebuild hers.

A poor, struggling South Carolinian mother and daughter face painful choices with their resolve and pride. Bone, the eldest daughter, and Anney her tired mother, grow both closer and farther apart: Anney sees Glen as her last chance.

When lapsed Jew and former cardiologist Harry suddenly decides to spend his retirement as a pig farmer in Nazareth, Israel, the move deeply shocks his family and his new neighbours. Back in New York, Harry’s ex-wife Monica is trying to manage the lives of their adult children, Annabelle and David, as well as her own.

Years after her son's suicide, a woman longs to confront both the past and a friend of his who took his business idea.

A psychotherapist helps a law student cope with schizophrenia in one of five interconnected tales dealing with mental illness.