The film starts out with ex-Captain Gantu on his new spaceship (his original got destroyed in the first film), being hired by a hamster-like alien named Dr. Jacques von Hämsterviel to retrieve the other 625 experiments.
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Now, we find the rowdy extraterrestrial getting used to life with his new ʻohana. However, a malfunction in the ultimate creation of Dr. Jumba soon emerges, which reinstates his destructive programming and threatens to both ruin his friendship with Lilo and to short him out for good!
Lilo, Stitch, Jumba, and Pleakley have finally caught all of Jumba's genetic experiments and found the one true place where each of them belongs. Stitch, Jumba and Pleakley are offered positions in the Galactic Alliance, turning them down so they can stay on Earth with Lilo, but Lilo realizes her alien friends have places where they belong – and it's finally time to say "aloha".
Phineas and Ferb travel across the galaxy to rescue their older sister Candace, who has been abducted by aliens and taken to a utopia in a far-off planet, free of her pesky little brothers.
As Stitch, a runaway genetic experiment from a faraway planet, wreaks havoc on the Hawaiian Islands, he becomes the mischievous adopted alien "puppy" of an independent little girl named Lilo and learns about loyalty, friendship, and ʻohana, the Hawaiian tradition of family.
When Earth astronaut Capt. Chuck Baker arrives on Planet 51 -- a world reminiscent of American suburbia circa 1950 -- he tries to avoid capture, recover his spaceship and make it home safely, all with the help of an empathetic little green being.