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Roy Applewood (Tom Wilkinson), after fainting on the night of 25th marriage anniversary, shocks his wife Irma (Jessica Lange) by revealing plans to transition into being out as a woman and change her name to Ruth. While Ruth tries to keep the family together, Irma's initial reaction is to separate from her. Patty Ann (Hayden Panettiere), their daughter, is more accepting, but Wayne (Joseph Sikora), their son, struggles with the transition. He mocks Ruth after receiving an explanation letter.