Melvin's saga continues as his partnership with Malcom is compromised by an urban superhero's intrusion. Meanwhile, Melvin's mother aids a criminal after being unable to meet with her son.
For their first day on the job as the new protectors of Metro City, Megamind and Minion are selling off the gadgets from their evil lair. But when one seemingly harmless "button" unleashes the gigantic robot MEGA-MEGAmind, the duo will have to resort to their old tricks to restore order.
Thanks to Green Goblin and Venom, tech theft is now at an all-time high. Can our Friendly Neighborhood Spider-Man put an end to their mysterious villainous scheme before all of New York City is destroyed?